Alex Holehouse

Assistant professor of biochemistry and molecular biophysics, School of Medicine

The Holehouse lab  explores how intrinsically disordered protein regions confer biological function and how this goes wrong in disease. The lab integrates physics-based models (all-atom and coarse-grained simulations) with informatics and machine learning to develop sequence-specific predictions. We then test those predictions either within the lab, or with collaborators around the world.Of particular interest is understanding how disordered proteins drive self-assembly in the context of biological phase separation, with a major emphasis on understanding when, how, and why this might be important for normal cellular function.