The Lew Lab builds advanced imaging systems to study biological and chemical systems at the nanoscale. Our technology leverages innovations in applied optics, signal and image processing, design optimization, and physical chemistry. We develop advanced nanoscopes (microscopes with nanometer resolution) that can visualize the activity of individual molecular machines inside and outside living cells. Examples of our technology include 1) using tiny fluorescent molecules as sensors that can detect amyloid proteins, 2) designing new “lenses” to create imaging systems that can visualize how molecules move and tumble, and 3) new imaging software that minimizes artifacts in super-resolution images.