Meredith Jackrel

Assistant professor of chemistry

Proteins must fold properly in order to function. When protein misfolding occurs, severe problems can arise. Protein misfolding underpins many devastating diseases including amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer’s disease. We are interested in understanding how protein misfolding occurs and how it can lead to disease. We are particularly interested in protein disaggregases, which can prevent and even reverse protein misfolding, solubilizing protein accumulations that are otherwise intractable. We aim to better understand how protein disaggregases solubilize such highly stable species. Additionally, we are employing various protein engineering techniques in order to fine-tune the properties of protein disaggregases.