Princess Imoukhuede’s research examines mechanisms regulating angiogenic signaling with focus on tyrosine kinase receptors, VEGFRs and PDGFRs. She pioneers both quantitative biological measurements and computational biological models to delineate ligand-receptor binding, receptor and effector phosphorylation, and sprouting angiogenic hallmarks (cell proliferation and migration). This bottom-up systems biology paradigm offers mechanistic insight towards directing vascular signaling with translational implications to cancers and cardiovascular diseases.
